Ataxia telangiectasia Evaluation of radiosensitivity in cultured skin fibroblasts
نویسندگان
چکیده
The sensitivity to x-ray inactivation of cultured skin fibroblasts from clinically confirmed and suspected cases of ataxia telangiectasia was compared with that of cultures from normal subjects. The results confirm previous observations of an association between ataxia telangiectasia and enhanced in vitro radiosensitivity, and also suggest that clonal survival of x-irradiated cultures of skin fibroblasts is a valuable technique for confirming the diagnosis of the disease.
منابع مشابه
Ataxia telangiectasia. Evaluation of radiosensitivity in cultured skin fibroblasts as a diagnostic test.
The sensitivity to x-ray inactivation of cultured skin fibroblasts from clinically confirmed and suspected cases of ataxia telangiectasia was compared with that of cultures from normal subjects. The results confirm previous observations of an association between ataxia telangiectasia and enhanced in vitro radiosensitivity, and also suggest that clonal survival of x-irradiated cultures of skin f...
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Hétérozygotes for ataxia telangiectasia (AT) are reported to have an increased risk of cancer especially prior to age 45 years. Cultured skin fibroblasts from some AT hétérozygotes are reported to show increased sensitivity to the lethal effects of X-irradiation under hypoxia which is intermediate between the response of AT homozygote and normal control fibroblasts. This in vitro colony for...
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The cancer-prone neurodegenerative disorder, ataxia telangiectasia (A-T), results from mutations of ATM (ataxia telangiectasia mutated). Individuals with A-T are also hypersensitive to ionizing radiation (IR). Cultured cells from A-T individuals or Atm-/- mice have cell cycle and growth defects and are generally considered radiosensitive. However, it has been shown recently that cell population...
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